Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications.
Key Insights
- Despite its high prevalence, the precise mechanisms underlying major depressive disorder (MDD) remain incompletely understood.
- Growing evidence identifies mitochondrial dysfunction, including abnormalities in mitochondrial DNA, impaired bioenergetics, disrupted quality control, and redox imbalance,.
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@misc{ acaciamarkets-research-mitochondrial-inflammation-crosstalk-in-major-depressive-dis,
title = { Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications. },
author = { Y Wang, JT Li, LL Zhu et al. },
year = { 2026 },
doi = { 10.1038/s41380-026-03732-y },
url = { https://pubmed.ncbi.nlm.nih.gov/42399415/ },
note = {Summarized and classified by AcaciaFund}
}
TY - GEN TI - Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications. AU - Y Wang, JT Li, LL Zhu et al. PY - 2026 DO - 10.1038/s41380-026-03732-y UR - https://pubmed.ncbi.nlm.nih.gov/42399415/ ER -
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Overview
Despite its high prevalence, the precise mechanisms underlying major depressive disorder (MDD) remain incompletely understood. Growing evidence identifies mitochondrial dysfunction, including abnormalities in mitochondrial DNA, impaired bioenergetics, disrupted quality control, and redox imbalance, as a central pathological feature of MDD. Beyond deficits in energy production, mitochondria function as upstream regulators of neuroinflammation.
Mitochondria derived damage associated molecular patt
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