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Altered perivascular water diffusivity links childhood trauma and major depressive disorder: A multimodal integration of cognition, neuroimaging, and transcriptomics.

Nov 1, 2026 Source ↗

Key Insights

Perivascular water diffusivity, as assessed by diffusion tensor imaging along the perivascular space (DTI-ALPS) index, serves as an indirect imaging marker potentially reflecting glymphatic function.
This study investigated its associations with childhood trauma and major depressive disorder (MDD) a.

Cite this synthesis DOI: 10.1016/j.jad.2026.122165 ↗

Show formatted citation

@misc{ acaciadata-research-altered-perivascular-water-diffusivity-links-childhood-traum,
  title = { Altered perivascular water diffusivity links childhood trauma and major depressive disorder: A multimodal integration of cognition, neuroimaging, and transcriptomics. },
  author = { M Wang, Y Yan, Y Dou et al. },
  year = { 2026 },
  doi = { 10.1016/j.jad.2026.122165 },
  url = { https://pubmed.ncbi.nlm.nih.gov/42336327/ },
  note = {Summarized and classified by AcaciaFund}
}

TY  - GEN
TI  - Altered perivascular water diffusivity links childhood trauma and major depressive disorder: A multimodal integration of cognition, neuroimaging, and transcriptomics.
AU  - M Wang, Y Yan, Y Dou et al.
PY  - 2026
DO  - 10.1016/j.jad.2026.122165
UR  - https://pubmed.ncbi.nlm.nih.gov/42336327/
ER  -

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Overview

Perivascular water diffusivity, as assessed by diffusion tensor imaging along the perivascular space (DTI-ALPS) index, serves as an indirect imaging marker potentially reflecting glymphatic function. This study investigated its associations with childhood trauma and major depressive disorder (MDD) and explored the related biological mechanisms.

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Article Metadata

Evergreen Synthesized

query-optimization dataops

Query Optimization DataOps

SQI 0.700